Addison's disease) when adrenal gland production of cortisol is chronically deficient. Conversely, chronically elevated ACTH levels occur in primary adrenal insufficiency (e.g. hypopituitarism) or tertiary adrenal insufficiency (disease of the hypothalamus, with a decrease in the release of corticotropin releasing hormone (CRH)). ĭeficiency of ACTH is an indicator of secondary adrenal insufficiency (suppressed production of ACTH due to an impairment of the pituitary gland or hypothalamus, cf. ACTH is also related to the circadian rhythm in many organisms. Its principal effects are increased production and release of cortisol and androgens by the cortex and medulla of the adrenal gland, respectively.
ACTH is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus). It is also used as a medication and diagnostic agent. Adrenocorticotropic hormone ( ACTH also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.
0 kommentar(er)
